This is particularly interesting given the fact that 24% of the general population is HLA DRB1*1501/DQB1*0602 positive. Several recent research studies have determined that these “ narcolepsy markers” are less likely to occur in people with T2N than in people with T1N and that people with T2N have markers that are more similar to those of folks with IH than those with T1N. For example, fewer than 40% of patients with TN2 are HLA positive (that is, they have at least one allele for DRB1*1501/DQB1*0602).
![cataplexy without narcolepsy cataplexy without narcolepsy](https://www.tomorrowsleep.com/wp-content/uploads/2018/08/Symptoms-of-Narcolepsy.jpg)
These factors, also called markers, include hypocretin levels, the results of HLA typing, and measures of sleep obtained via the Multiple Sleep Latency Test ( MSLT) and one or more of the following: actigraphy, polysomnography, and sleep diaries. Over the past few years as researchers have studied the spectrum of hypersomnolence disorders, they not only have separated narcolepsy into two types (now called type 1 and type 2 in ICSD-3), but also have identified factors that differentiate the central disorders of hypersomnolence. This research was completed before the publication of the International Classification of Sleep Disorders (ICSD-3) in 2014, and therefore the researchers based their classifications on ICSD-2 criteria. Jin Diagnosis, Idiopathic Hypersomnia, Journal Article Summaries, Narcolepsy Researchers have provided more evidence that narcolepsy without cataplexy (Nw/oC ) and idiopathic hypersomnia (IH) without long sleep time (LST) look more alike on testing than do narcolepsy with cataplexy (NwC) and Nw/oC.
![cataplexy without narcolepsy cataplexy without narcolepsy](https://images.everydayhealth.com/images/sleep-disorders/narcolepsy/narcolespy-guide-cataplexy-722x406.jpg)
Cataplexy without narcolepsy update#
International Patient Registry – Join or Update Your Data.Guides for Working With People With Hypersomnias.International Healthcare Provider Directory.